Among these tissues, the liver is the major site of alcoholinduced damage because it directly receives blood containing high concentrations of alcohol and is the major organ of ethanol metabolism, producing toxic metabolites from alcohol karinch et al. The aim of this study was to investigate the protective effects of erdosteine on apap induced hepatotoxicity in rats. It was observed that the rats treated with ccl 4 significantly altered the biochemical parameters in serum compared to normal group of rats table 1. The protective effects of aqueous extracts of the fruit rind of garcinia indica gie on ethanolinduced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. Hepatoprotective effect of ethanol extract from berchemia lineate against ccl4induced acute hepatotoxicity in mice cong li, litao yi, di geng, yuanyuan han, and lianjin weng pharmaceutical biology downloaded from by university of.
The atorvastatin was able to prevent the ethanolinduced hepatotoxicity by. Assessment of hepatoprotective activity of rajata bhasma. We investigated the effects of ra 10 mgkg against ethanol induced oxidative damage and hepatotoxicity in rats. A relatively smaller decline in cytosolic aldh activity was observed in cc14 treated rats with or without ethanol preexposure. Increased hepatotoxicity of acetaminophen after chronic. Effects of erdosteine on acetaminopheninduced hepatotoxicity. Supplementation with the hydrophobic bile salt cdc aggravates ethanol induced damage, whereas the administration of the hydrophilic bile salt udc has a protective effect. Administering ellagic acid to rats with ethanolinduced hepatotoxicity was shown to ameliorate the increased serum levels of aminotransferases, lipid peroxides, and hydroperoxides and also to reduce the elevated hepatic contents of cholesterol, free fatty acids, triglycerides, and phospholipids.
Extract ameliorates chronic ethanolinduced hepatotoxicity in albino rats. Antioxidant and antiinflammatory role of zingerone in. Protective effect of hericium erinaceus on alcohol induced. In this study, we investigated the effect of carnosine pretreatment on ethanol induced oxidative stress and hepatotoxicity. Hepatoprotective effect of rosa canina fruit extract against. Lieber alcohol research and treatment center and laboratory of liver disease and nutrition, bronx veterans administration medical center and mt. In the present study, we evaluated the protective effects of gte against ethanol induced hepatotoxicity. The role of tumor necrosis factor in acute endotoxin. Rosmarinic acid attenuates the hepatotoxicity induced by. Dec 25, 2007 the antioxidant effect of the ethanolic root extract of hemidesmus indicus, an indigenous ayurvedic medicinal plant used in soft drinks in india, was studied in rats with ethanol induced hepatotoxicity. The data suggest that inhibition of membrane bound aldh may be one of the major mechanisms of in vivo potentiation of cc14induced hepatotoxicity by ethanol. In this study, we investigated the effect of carnosine pretreatment on ethanolinduced oxidative stress and hepatotoxicity.
Lcarnitine inhibits ethanolinduced gastric mucosal. Hepatotoxicity was induced by administering oral doses of ccl4 1. Journal of the college of physicians and surgeons pakistan 2011, vol. The present study was carried out to evaluate the hepatoprotective effect and antioxidant role of grape vitis vinifera l.
Hepatoprotective activity of sphaeranthus amaranthoides on dgalactosamine induced hepatitis in albino rats. Lcarnitine inhibits ethanolinduced gastric mucosal injury. However, the roles of hem on alcohol induced hepatotoxicity have not been reported. Lcarnitine is a quaternary amine that is essential for the normal oxidation of longchain fatty acids by mitochondria. Ethanol etoh causes a further substantial amount of liver insufficiencies world wide. The protective effects of aqueous extracts of the fruit rind of garcinia indica gie on ethanol induced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. Hepatoprotective effect of rosa canina fruit extract.
Previous studies showed statins reduce lipid peroxidation and attenuate free radical. Prevention of ethanolinduced liver injury in rats by an agonist of peroxisome proliferatoractivated receptorgamma, pioglitazone. Protection of hepatotoxicity using spondias pinnata by. The antioxidant effect of the ethanolic root extract of hemidesmus indicus, an indigenous ayurvedic medicinal plant used in soft drinks in india, was studied in rats with ethanolinduced hepatotoxicity. Effect of 50% ethanolic extract of bixa orellana on body weight, liver weight and relative liver weight in control and 40% ethanol induced hepatotoxicity in rats. Rosmarinic acid ra, a natural polyphenolic compound, shows some biological activities including antioxidant and antiinflammatory activity. Hepatoprotective activity of rb was determined in cc1 4 induced hepatotoxicity rats. Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat chifumi sato, yoshiro matsuda, and charles s. The effects of this lecithin as a hepatoprotective drug on body weight and antioxidant status of ethanol exposed rats were studied. The results indicated that gs could be as important as dietderived antioxidants in preventing oxidative damage in the tissues by reducing the lipid oxidation or inhibiting the production of ethanolinduced free radicals in rats. Effects of nacetylcysteine on ethanol induced hepatotoxicity in rats fed via total enteral nutrition author links open overlay panel martin j. Acarbose alone or in combination with ethanol potentiates. The effect of carnosine pretreatment on oxidative stress and.
Pdf effect of ethanol extract of pyrenacantha staudtii. Ronis mj, butura a, sampey bp, shankar k, prior rl, korourian s, et al. Modulatory effect of methanol extract of piper guineense in. Pdf twelve male albino rats of 68 weeks old, weighing 150200 gm each were divided into two groups of 6 rats each. The effects of this lecithin as a hepatoprotective drug on body weight and antioxidant status of ethanolexposed rats were studied. For example, ethanolinduced hepatotoxicity in animal models requires diets that have a high percentage of the total calories as unsaturated fat. The overall body weight of rats in formulation groups was increased while the liver weight was significantly reduced by all the formulation groups in ccl 4, ethanol, and paracetamolinduced hepatotoxicity models in rats. Walther leaf extract counteracts oxidative stress induced by ethanol and carbon tetrachloride coinduced hepatotoxicity in rats by wenwan chao 1, shuju chen 2, huichen peng 2, jiunnwang liao 3 and sutze chou 2.
This study seeks to investigate the possible protective role of the methanol extract of piper guineense seeds against ccl4 induced hepatotoxicity in an animal model. The current study is, therefore, designed to determine the effect of silymarin on the serum levels of alt and ggt in. Effects of nacetylcysteine on ethanol induced hepatotoxicity in rats fed via total enteral nutrition martin j. Rats were given carnosine 2 gl in drinking water for 4 weeks and then ethanol was administered orally to rats at a dose of. The results were compared with the effects of tocopheryl acetate. After 6 wk of diet, all rats were injected with 1 mgkg lipopolysaccharide or 0. Rats of groups 1 and 2 received isocaloric glucose. This study seeks to investigate the possible protective role of the methanol extract of piper guineense seeds against ccl4induced hepatotoxicity in an animal model. It had shown that the beneficial effects of this phytochemical in preventing the ethanol induced hepatotoxicity are mediated by the antioxidant effects. The present study was designed to evaluate the antioxidant activity of livomap on ethanol induced hepatotoxicity in albino wistar rats.
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the united states. All animals were divided into 4 groups in the study for a 5week duration. Antioxidant effect of hemidesmus indicus on ethanol. Prevention of ethanol induced liver injury in rats by an agonist of peroxisome proliferatoractivated receptorgamma, pioglitazone. Alcoholic liver disease is a direct result of alcoholinduced hepatotoxicity coupled with impaired hepatic regenerative activity. B 250 mgkg and 500 mgkg produced p pdf free classifications. Antioxidant effect of livomap, a polyherbal formulation on. Antioxidant effect of hemidesmus indicus on ethanolinduced. Hepatotoxicity was induced on the rats using ethanol and the levels of serum enzymes such as serum glutamic pyruvic transaminase sgpt, serum glutamic oxaloacetic transaminase sgot, total and conjugated bilirubin were estimated. The effect of carnosine pretreatment on oxidative stress. Administering 20% ethanol 5 gkg of body weightday for 60 days to male wistar rats resulted in significantly decreased body weight and.
Rats were given carnosine 2 gl in drinking water for 4 weeks and then ethanol was administered orally to rats at a dose of 5 gkg every 12 hours for 3 doses totally binge model. Effects of nacetylcysteine on ethanolinduced hepatotoxicity in rats fed via total enteral nutrition author links open overlay panel martin j. Screening of liver protective effect of ethanolic leaf extract of callicarpa lanata eecl in ethanol induced hepatotoxicity in wister rats article pdf available february 2019 with 91 reads. At the end of the treatment period, rats were weighed and use for biochemical, molecular, and histopathological examinations. Monika singh 1, pranay wal 1, ankita wal 1 and shubhangi srivastava 2. Prior a sohelia korourian e emanuele albano f magnus ingelmansundberg c dennis r. Our aim of the study was to investigate the beneficial effect of zingerone on hepatic oxidative stress and inflammation induced by ethanol in experimental rats. Modification of hexavalent chromate hepatotoxicity by ethanol extract of moringa oleifera in wistar rats. Prior, a sohelia korourian, e emanuele albano, f magnus ingelmansundberg, c dennis r. Alcohol has been reported to affect a variety of tissues in the human body lieber 2000. Walther leaf extract counteracts oxidative stress induced by ethanol and carbon tetrachloride co induced hepatotoxicity in rats by wenwan chao 1, shuju chen 2, huichen peng 2, jiunnwang liao 3 and sutze chou 2.
Pdf twelve male albino rats of 68 weeks old, weighing 150200 gm each were divided. Green tea extract ameliorates ethanol induced liver injury in albino rats poonam lodhi1, neeraj tandan2, neera singh1, divyansh kumar3 1environmental endocrinology and biomedical research unit, department of zoology, meerut college, meerut 250003, india. Ld was carried out and found to be between the ranges of 1900mgkg to 50. It indicated that the free radicals being released in the liver were effectively scavenged by hem. Antioxidant activity of graptopetalum paraguayense e. Effects of nacetylcysteine on ethanolinduced hepatotoxicity in rats fed via total enteral nutrition.
We investigated the effects of ra 10 mgkg against ethanolinduced oxidative damage and hepatotoxicity in rats. Silymarin protects against acute ethanolinduced hepatotoxicity in. Introduction paracetamol or acetaminophen apap is one of the most. Alcohol, oxidative stress, and free radical damage. From the present study, it can be concluded that ethanolinduced stress can be partly prevented by tocopheryl acetate, and showed best result. Our study demonstrated that high doses of acarbose, alone or in combination with ethanol, can potentiate ccl 4 and ap hepatotoxicity in rats by inducing hepatic cyp2e1. Male albino wistar rats were divided into four groups. Pharmacological evaluation of hepatoprotective activity of. Liver damage was induced in rats by administering ethanol 5 gkg, 20% wv p. Groups 1 and 2 rats received isocaloric glucose and 0. The aim of this study was therefore to compare the effects of cdc and udc on chronic ethanol hepatotoxicity in rats and to determine whether udc could be effective in preventing liver damage in rats coadministered ethanol and cdc. Short communication effect of methanolic extract of hibiscus. Pdf ethanol induced hepatotoxicity in albino rats researchgate.
Effect of methanol extract of gomphrena celesioides on. In this study, ethanol leaf extract of jatropha curcas were selected for their hepatoprotective activity on experimentally induced hepatotoxicity in rats. Ethanolinduced hepatotoxicity in male wistar rats semantic scholar. Green tea extract ameliorates ethanol induced liver injury in. Besides serving as a substrate for gshrelated enzymes, gsh acts as a free radical. The effect of ethanol extract of pyrenacantha staudtii leaves on carbontetrachloride ccl4 induced hepatotoxicity in rats was studied.
Ethanol administration increased the bal, which caused the changes in the behavior of rats. Sixteen male wistar rats of 100170g body weight divided. However, little attention has been given to the role of carbohydrates or carbohydrate to fat ratio in the effects of. For example, ethanol induced hepatotoxicity in animal models requires diets that have a high percentage of the total calories as unsaturated fat.
Groups 3 and 4 received 20% ethanol, equivalent to 5 g. Lcarnitine inhibits ethanol induced gastric mucosal injury in rats dikmen dokmeci1, meryem akpolat2, nurettin aydogdu3, latife doganay4, f. The leaves ofjatropha curcas were sundried, ground and then extracted with ethanol. Antioxidant effect of hemidesmus indicus on ethanolinduced hepatotoxicity in rats article pdf available in journal of medicinal food 104. We investigated the effects of hericium erinaceus hem on liver injury induced by acute alcohol administration in mice. Effects of nacetylcysteine on ethanolinduced hepatotoxicity. The overall body weight of rats in formulation groups was increased while the liver weight was significantly reduced by all the formulation groups in ccl 4, ethanol, and paracetamol induced hepatotoxicity models in rats. Acarbose alone or in combination with ethanol potentiates the. A total of 30 rats were divided into five groups of six rats in each group. After induction of liver toxicity the aqueous plant. Implication of free radical mechanisms in ethanolinduced cellular injury.
To investigate the protective effect of the leaf extract of andrographis paniculata ap against ethanol induced liver toxicity in male albino rats. Pdf screening of liver protective effect of ethanolic. This indicates the prevention of hepatotoxicityrelated fatty changes in liver and improvement in liver function which leads. Our aim was to investigate the effect of naringenin on hyperlipidemia induced by ethanol. Aug 20, 2016 alcoholic liver disease is a direct result of alcohol induced hepatotoxicity coupled with impaired hepatic regenerative activity.
Antioxidants free fulltext antioxidant activity of. Hepatoprotective and antioxidant activities of grapeseeds. Forty adult male albino rats were divided into four groups as control, etoh 3 g. The effect of ethanol leaf extract of jatropha curcas on. A nutritionally adequate diet was purchased from uar villemoisson, france. Original article antioxidant and hepatoprotective effect of. Ethanolinduced hepatotoxicity has been reported to cause significant increase in the values of serum alanin aminotransferase and gammaglutamyl transferase. Mice received ethanol 5 gkg bw by gavage every 12 hrs for a total of 3 doses. Administering 20% ethanol 5 gkg of body weightday for 60 days to male wistar rats resulted in significantly decreased body weight and increased liverbody weight ratio. Jan 01, 2002 the results of the present investigation indicate that bile salts modulate hepatic disorders induced by chronic ethanol feeding in rats. Hepatoprotective effect of the aqueous extract of the roots of decalepis hamiltonii against ethanolinduced oxidative stress in rats. Hepatoprotective potential of andrographis paniculata. Atorvastatin attenuates ethanolinduced hepatotoxicity via.
This indicates the prevention of hepatotoxicity related fatty changes in liver and improvement in liver function which leads. Hepatoprotective potential of andrographis paniculata aqueous. From the present study, it can be concluded that ethanol induced stress can be partly prevented by tocopheryl acetate, and showed best result. Modification of hexavalent chromate hepatotoxicity by. Effect of lecithin in the treatment of ethanol mediated.
Prevention of ethanolinduced liver injury in rats by an. The objective of the present study is to investigate the protective effect of orally administered rosmarinic acid ra on ethanol etoh induced hepatotoxicity in rat liver. The final body weight of normal group i rats showed 201. Original article antioxidant and hepatoprotective effect. Can phytochemicals be effective in preventing ethanol. The objective of the present study is to investigate the protective effect of orally administered rosmarinic acid ra on ethanol etohinduced hepatotoxicity in rat liver. Mechanisms of alcoholinduced hepatotoxicity 43 table 1. Can phytochemicals be effective in preventing ethanolinduced. Effect of lecithin in the treatment of ethanol mediated free. However, little attention has been given to the role of carbohydrates or carbohydrate to fat ratio in the effects of this important xenobiotic on liver injury.
Short communication effect of methanolic extract of. Silymarin protects against acute ethanolinduced hepatotoxicity in mice. B 250 mgkg and 500 mgkg produced p in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mgkg showed remarkable decline in alt, ast, alp and tb levels, compared to the reference. Hepatoprotective activity of ethanol extract of conyza b. Rats fed ethanol from 21 to days were subjected to one or more episodes of hypoxia 6% o2 in order to determine if ethanol predisposed to centrilobular liver necrosis induced by hypoxia. Paracetamol induced experimental liver damage in case of paracetamol induced hepatotoxicity, the rats were divided into 5 groups of 6 rats each. Seed extract against acute ethanolinduced hepatotoxicity in rats html full text.
Group 1 control and group 2 ccl4 were left untreated. The liver toxicity was induced by the administration of ethanol to the animals at the optimum dosage of 7. Lcarnitine inhibits ethanolinduced gastric mucosal injury in rats dikmen dokmeci1, meryem akpolat2, nurettin aydogdu3, latife doganay4, f. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The hepatoprotective and antioxidant roles of the gs supplementation feed against ethanolinduced oxidative stress were evaluated by measuring liver damage serum marker enzymes, aspartate aminotransferase, alanine. The goal of this study was to investigate the hepatoprotective effects of aqueous extract of camellia sinensis or green tea extract aqgte in chronic ethanolinduced albino rats. Modulatory effect of methanol extract of piper guineense. Pdf antioxidant effect of hemidesmus indicus on ethanol. Among these tissues, the liver is the major site of alcohol induced damage because it directly receives blood containing high concentrations of alcohol and is the major organ of ethanol metabolism, producing toxic metabolites from alcohol karinch et al. Administering ellagic acid to rats with ethanol induced hepatotoxicity was shown to ameliorate the increased serum levels of aminotransferases, lipid peroxides, and hydroperoxides and also to reduce the elevated hepatic contents of cholesterol, free fatty acids, triglycerides, and phospholipids. Objectives to evaluate the effect of chrysin, a natural, biologically active compound extracted from many plants, honey and propolis, on the tissue and circulatory antioxidant status, and lipid peroxidation in ethanol. Subsequent serum alanine aminotransferase alt level, aspartate aminotransaminase ast level, maleic dialdehyde mda. Hem 200 mgkg bw was gavage before ethanol administration.
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